Inhibition of NF- B potentiates amyloid -mediated neuronal apoptosis
نویسندگان
چکیده
منابع مشابه
Inhibition of NF-kB potentiates amyloid b-mediated neuronal apoptosis (IkB-aytumor necrosis factoryoxidative stressyneuroprotectionypreconditioning)
One mechanism leading to neurodegeneration during Alzheimer’s disease (AD) is amyloid b peptide (Ab) neurotoxicity. Ab elicits in cultured central nervous system neurons a biphasic response: a low-dose neurotrophic response and a high-dose neurotoxic response. Previously we reported that NF-kB is activated by low doses of Ab only. Here we show that NF-kB activation leads to neuroprotection. In ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.16.9409